Na( )-K( )-Cl(-) cotransporter

Pathways Recommended:	PI3K/Akt/mTOR

By Targets:	NKCC (7) GABA Receptor (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Metabolic Disease (7)

Targets Recommended: Na+/HCO3- Cotransporter NKCC Na+/Ca2+ Exchanger Na+/K+ ATPase Na+/H+ Exchanger (NHE) Chloride Channel Sodium Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17468

Bumetanide 3 Publications Verification Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a *Na ⁺-K ⁺-Cl* ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀**s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-B0135

Furosemide 2 Publications Verification	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-B0135A

Furosemide sodium 2 Publications Verification	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide sodium is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide sodium is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-17468A

Bumetanide sodium Ro 10-6338 sodium; PF 1593 sodium	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide sodium, a highly potent loop diuretic, is a *Na ⁺-K ⁺-Cl* ⁺ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC₅₀**s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-17468R

Bumetanide (Standard) Ro 10-6338 (Standard); PF 1593 (Standard)	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Standard) is the analytical standard of Bumetanide. This product is intended for research and analytical applications. Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a *Na ⁺-K ⁺-Cl* ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀**s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-B0135S

Furosemide-d5	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

HY-B0135R

Furosemide (Standard)	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide (Standard) is the analytical standard of Furosemide. This product is intended for research and analytical applications. Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^-?(NKCC) cotransporter, NKCC1 and NKCC2 .?Furosemide is also a GABA_A?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

Cat. No.	Compare	Product Name	Species	Source

HY-P702022

	SLC12A2 Protein, Human (Sf9, His, Strep, FLAG) SLC12A2; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2	Human	Sf9 insect cells
	SLC12A2 Protein mediates electroneutral transport of chloride, potassium, and/or sodium ions across the membrane, crucial for regulating ionic balance and cell volume. SLC12A2 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived SLC12A2 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of SLC12A2 Protein, Human (Sf9, His, Strep, FLAG) is 1211 a.a., .


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Cat. No.	Product Name	Chemical Structure

HY-B0135S

Furosemide-d5
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

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Recombinant Proteins

Isotope-Labeled Compounds

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